Figure 1.

Chromatin engaging technologies and gene regulation systems. (a) Chromatin engaging technologies. ZF (zinc finger), TALE (transcription activator-like effector), dCas9, and polyamides are chromatin-engaging techniques used for precise gene targeting, often fused directly to effector proteins. (b) Gene regulation systems. Examples of different effectors used in chromatin engaging technologies. By fusing repressive or activating effectors to chromatin engaging platforms, gene regulation can be achieved.