Table 1.

Histone and DNA writers, readers, and erasers modified in diseases.

Mutated Writers, Readers, and Erasers	Alteration	Disease(s)
DNMT3A	Missense, Frameshift, Nonsense, Splice site	AML [146], MDS [147]
TET1	Translocation	AML [148]
TET2	Missense, Nonsense, Frameshift	MPN [149], AML [150], MDS [151], CMML [152]
CBP/KAT3A	Translocation, Nonsense, Missense, Frameshift	AML [153,154], DLBCL [155], MDS [156], RTS [157]
P300/KAT3B	Translocation, Nonsense, Missense, Frameshift	CML [158], Pancreatic [159], Colorectal [159], Breast [159], DLBCL [155], AML [160]
MOZ/KAT6A	Translocations	AML [160,161]
MORF/KAT6B/MYST4	Translocations	AML [153], Uterine Leiomyomata [162]
BRD2	Unknown	ALL [163]
BRD3	Translocation, Missense	Midline Carcinoma [164], Lung [165]
BRD4	Translocation	Midline Carcinoma [166]
TRIM33	Translocation	Lung [167]
KMT2A/MLL1	Partial Tandem Duplication, Translocation	AML [168], ALL [169]
KMT2B/MLL2	Nonsense, Frameshift, Missense	Medulloblastoma [170], Breast [171], Renal [172], DLBCL [173], Prostate [174], FL [173], Lung [175]
KMT2X/MLL3	Nonsense	Medulloblastoma [170], Breast [171]
KMT3A/SETD2	Nonsense, Frameshift, Missense	Renal [172], Breast [171]
KMT3B/NSD1	Translocation	AML [176]
NSD2	Translocation, Missense	Multiple Myeloma [177], ALL [178]
NSD3	Translocation	AML [179]
KMT6/EZH2	Missense	DLBCL [180], MPN [181], MDS [182]
KDM5A/JARID1A	Translocation	AML [183]
KDM5C/JARID1C	Nonsense, Frameshift, Splice site	Renal [172]
KDM6A/UTX	Deletion, Nonsense, Frameshift, Splice site	AML [184], Renal [184], Esophageal [184], Multiple Myeloma [184], CML [184]
PHF6	Deletion, Missense	T-ALL [185], AML [186]
BRD8	Missense, Nonsense	Liver [187]
DNMT1	Nonsense, Missense	Colon [188]
HDAC2	Frameshift	Colon [189]
HDAC9	Missense	Prostate [190]
PRDM9	Nonsense, Missense	Head and Neck [191]
SETD2	Frameshift, Nonsense, Splicing site	Glioblastoma [192], Renal [193]
SETD1A	Nonsense	Breast [171]