Figure 2.

Neutrophil responses to viral infection. Neutrophils have an important role in antiviral immunity. (a) Neutrophils are recruited to sites of viral infection in the lung via signaling through MyD88 and TRIF. Interleukin-1β production by the NLRP3 inflammasome in resident antigen presenting cells drives recruitment. (b) once in the tissue, MAVS signaling initiates neutrophil activation and production of inflammatory mediators. Neutrophils engulf antibody-bound virions via surface Fc receptors. (c) The inhibitory receptor LAIR-1 binds collagen and suppresses neutrophil activity. (d) Transcriptional regulators such as BCL6 suppress apoptosis and represent a potential target for enhancing neutrophil-mediated antiviral immunity.