Table 1.

Diverse roles of neutrophil signaling and effector proteins. Neutrophil effector proteins, such as proteases and phagocytic receptors, and receptors involved in chemotaxis, contribute to the plasticity of neutrophils in driving inflammation, promoting resolution, or maintaining homeostasis. Abbreviations: Arg1, arginase-1; iNOS, inducible nitric oxide synthase; LAIR-1, leukocyte-associated Ig-like receptor 1; MPO, myeloperoxidase; MMP-9, matrix metalloproteinase-9; NOX, nicotinamide adenine dinucleotide phosphate oxidase; NE, neutrophil elastase; oxCAMKII, oxidized calmodulin-dependent protein kinase II.

Protein	Role	Function
Arg1	pro/anti-inflammatory	suppresses T-cell proliferation [4]
BCL6	pro/anti-inflammatory	suppresses neutrophil apoptosis [20]
CD200R	anti-inflammatory	attenuates oxidant production by neutrophils [21]
CXCR2	pro-inflammatory	promotes chemotaxis as receptor for CXCL1 [22]
CXCR4	homeostatic	promotes retention in bone marrow/lung as receptor to CXCL12, [23]
Dectin-1	pro-inflammatory	promotes phagocytosis of fungi [24]
iNOS	pro-inflammatory	supports the generation of nitric oxide [25]
LAIR-1	anti-inflammatory	suppresses neutrophil recruitment [26,27]
MPO	pro-inflammatory	supports generation of hypochlorous acid [28]
MMP-9	pro-inflammatory	degrades the extracellular matrix [29]
NOX	pro-inflammatory	supports the generation of superoxide [1]
NE	pro-inflammatory	degrades phagocytosed microbes [1] and extracellular matrix [30]
oxCAMKII	pro-inflammatory	activates STAT1 and generation of inflammatory mediators [10]