Figure 2.

Overview of housing conditions and timeline of the experiment. At ~3–4 months of age, C57Bl/6 and Tg-SwDI female mice were randomly assigned to one of four housing conditions: SIN (single housed), COG (single housed with cognitively stimulating toys switched out twice weekly), SOC (group housed), and EE (group housed mice with toys and running wheel). Following 4 months in the respective housing conditions, mice underwent a battery of behavior tests, and tissue was collected (end age = ~8–9 months). Within housing conditions, access to a running wheel is indicated by the presence of an orange exercise saucer. Cognitive enrichment is indicated by the presence of multi-colored blocks, balls, and tunnels.