Figure 4.

Activity and temperament measures. (A) Rotarod performance measured by time spent on rod (average of best two of three trials), indicative of balance and motor coordination. Under SIN conditions, Tg-SwDI mice were impaired in this task, while EE housing improved performance in both WT and Tg-SwDI mice. (B) Wire hang performance measured by time spent hanging onto a wire, indicative of forelimb strength. EE housing improved performance, but this was only significant in WT mice. (C) General activity levels, as measured by the distance traveled in the open field. SOC housing increased activity in WT mice. Overall, Tg-SwDI mice were hypoactive and this was exacerbated in EE mice. (D) Anxiety-like behavior, as measured by the percent of distance traveled in the center of the open field arena. Overall, Tg-SwDI mice exhibited increased anxiety-like behavior (less center activity), while anxiety was reduced by EE housing in both WT and Tg-SwDI mice. E and F) Exploratory behavior, as measured by the number of arm entries (E) and speed of travel (F) in the radial arm maze task. Generally, Tg-SwDI mice exhibited lower levels of exploration, and the number of arm entries was increased in SOC mice. In WT mice, SOC and EE housing increased the number of arm entries as well. (G) Time spent digging in a marble-burying task. Generally, Tg-SwDI mice exhibited lower levels of digging behavior, while EE housing attenuated digging behavior in both WT and Tg-SwDI mice. * p < 0.05 vs. SIN of the same genotype, @ p < 0.05 vs. COG of the same genotype, % p < 0.05 vs. SOC of the same genotype, # p < 0.05 vs. EE of the same genotype, ^ p < 0.05 vs. WT in the same housing condition.