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After 21 days of treatment, the major organs (heart, kidney, liver, lung and spleen) were harvested from mice and then stained with H&E. Cyclophosphamide at different schedules was given for three weeks. The mice were killed on day 22 and tissues were collected and H&E staining was performed. MTD: 3 doses of 150 mg/kg each, for the first week only; Met-1: 170 mg/kg every 6 days; Met-2: 25 mg/kg every other day. ×400.
