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. 2020 Jan 21;21(3):704. doi: 10.3390/ijms21030704

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Alterations in patterns of lipid mediators in rabbit AH under conditions of LIRD. The animals were illuminated with intense visible light (30,000 lx) for 3 h (the course of the illumination is shown as gray box). AH samples were collected before (norm) and immediately after (3 h) the illumination as well as on 1, 3, and 7 day post-exposure. The concentrations of the lipid mediators (phospholipid derivatives, PUFAs and oxylipins) in aqueous AH were measured using quantitative UPLC-MS/MS analysis. * p > 0.05 as compared to the parameters of AH of the intact (control) animals. The identified oxylipins are divided into subgroups according to their origin and biosynthetic pathways, involving cyclooxygenases (COX), lipoxygenases (LOX), cytochrome P450 monooxygenases (CYP), or reactive oxygen species (ROS) (non-enzymatic pathway).