Table 2.

Multicomponent synthesis of dihydropyridine-based heterocyclic systems 157–161 of potential anticancer activity.

Reagents				Conditions	Product	Reference
Ar1CHO 1	ArCOMe 16	38	AcONH4	EtOH, reflux	157 a	[176]
		12			158 a
	8	8	ArNH2 2	PEG-400, 200 W, 80 °C	159 b	[177]
	27	27	(NH4)2CO3		160 b
	47	12	ArNH2 2	Montmorillonite-K10, H2O/EtOH (2:1), 60 °C	161 c	[178]

^a For compounds 157/158: Ar¹ = 2-HOC₆H₄, 2-ClC₆H₄, 3-ClC₆H₄, 2,5-(MeO)₂C₆H₃, 2,4-(MeO)₂C₆H₃, 3-thienyl, 4-EtOC₆H₄, 2-EtOC₆H₄, 4-MeOC₆H₄, 2-MeOC₆H₄, 4-ClC₆H₄; Ar = 4-BrC₆H₄, 3-BrC₆H₄, 2-BrC₆H₄, Ph, 3-thienyl. ^b For compounds 159/160: Ar¹ = 3-NO₂C₆H₄, 3-PhOC₆H₄, 3-ClC₆H₄, 4-HO-3-MeOC₆H₃, 4-Me₂NC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 4-MeSC₆H₄, 3-BrC₆H₄, 2-ClC₆H₄, Ph, 2-NO₂C₆H₄, 3-MeC₆H₄, 2-MeC₆H₄; Ar = 4-MeSC₆H₄, 4-MeOC₆H₄, 3-NO₂C₆H₄, 4-ClC₆H₄, 3-MeOC₆H₄, 4-HO-3-MeOC₆H₃. ^c For compounds 161: X = Me, Et; Ar¹ = Ph, 4-BrC₆H₄, 3-BrC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 3-MeC₆H₄, 2-HOC₆H₄; Ar = Ph, 4-MeOC₆H₄, 4-BrC₆H₄, 4-IC₆H₄, 4-FC₆H₄, 4-NO₂C₆H₄.