Table 3.

Multicomponent synthesis of fused dihydroquinolines 162–165 for evaluation of their potential anticancer properties.

Reagents			Conditions	Product	Reference
27	ArCHO 1	2	AcOH, MWI, 120 °C	162 a	[145]
94	RCHO 1	2	L-Proline, EtOH, reflux	163 b	[181]
27	ArCHO 1	2	EtOH, reflux	164 c	[182]
10a			EtOH, MWI, 150 °C	165 d	[183]

^a For compounds 162: Ar = 4-FC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 3-NO₂C₆H₄, 4-NO₂C₆H₄, Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 2,4-(Cl)₂C₆H₃, 4-HO-3-NO₂C₆H₃, 3,4,5-(MeO)₃C₆H₂, 2-thienyl. ^b For compounds 163: R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 3-MeOC₆H₄, 4-ClC₆H₄, 2-ClC₆H₄, 4-FC₆H₄, 2-FC₆H₄, 3-NO₂C₆H₄, 4-NO₂C₆H₄, 3,4-(Cl)₂C₆H₃, 2,4-(Cl)₂C₆H₃, 2,5-(MeO)₂C₆H₃, 3,5-(MeO)₂C₆H₃, 3,4,5-(MeO)₃C₆H₂, 2-furyl, 2-thienyl, Me. ^c For compounds 164: Ar = 3,4-(MeO)₂C₆H₃, 3,4,5-(MeO)₃C₆H₂, 2,4-(F)₂C₆H₃, 3,4-(HO)₂C₆H₃, 4-ClC₆H₄, 4-HO-3,5-(MeO)₂C₆H₂, 4-CNC₆H₄, 3-BrC₆H₄, 4-FC₆H₄, 4-MeOC₆H₄, 3-CF₃C₆H₄, 4-iPrC₆H₄, 4-MeC₆H₄, Ph, 2-naphthyl, 3-MeOC₆H₄, 2-thienyl, 3-HOC₆H₄, 2-FC₆H₄, 4-BrC₆H₄. ^d For compounds 165: R = H, Me; Ar = 4-ClC₆H₄, 3,4-(MeO)₂C₆H₃, 4-CF₃C₆H₄, 4-iPrC₆H₄, 3,4,5-(MeO)₃C₆H₂, 4-BrC₆H₄, 4-HO-3-MeOC₆H₃, 4-HO-3,5-(MeO)₂C₆H₂, 3,4-(OCH₂O)C₆H₃, 4-MeC₆H₄, 4-MeOC₆H₄, 3-CF₃C₆H₄, 1-naphthyl, 2-thienyl, 5-Me-2-thienyl.