Table 5.

Multicomponent synthesis of cyclopentanone-based dihydropyran/dihydropyridine heterocyclic systems 234–238 of potential anticancer activity.

Reagents				Conditions	Product	Reference
12/38 X = CN, CO2Et, CONH2	16	ArCHO 1	TEA	EtOH, reflux	234 a	[231]
		1			235 b
		ArCHO 1	AcONH4		236 a
		1			237 b
119	PhCHO 1	CH2(CN)2 12	-----	1,4-dioxane, TEA, reflux	238

^a For compounds 234/236: X = NH₂, OH; Y = CN, CONH₂; Ar = Ph, 2-furyl, 4-MeOC₆H₄. ^b For compounds 235/237: X = NH₂, OH.