TABLE 1.
Strain IDa | MIC (mg/liter) data for drugb: |
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ciprofloxacin |
Tetracycline |
Cefixime |
Ceftriaxone |
Penicillin |
Azithromycin |
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MICpred | MICpub | MICpheno | MICpred | MICpub | MICpheno | MICpred | MICpub | MICpheno | MICpred | MICpub | MICpheno | MICpred | MICpub | MICpheno | MICpred | MICpub | MICpheno | |
WHO-F | ≤0.004 | 0.004 | 0.004 | ≤0.25 | 0.25 | 0.5 | ≤0.008 | <0.016 | 0.002 | ≤0.004 | 0.001 | 0.001 | ≤0.125 | 0.032 | 0.032 | ≤0.125 | 0.125 | 0.125 |
WHO-G | 0.25 | 0.125 | 0.125 | 32 | 32 | 16 | 0.016 | <0.016 | 0.016 | 0.008 | 0.008 | 0.008 | 1 | 0.5 | 0.5 | 0.25 | 0.25 | 0.25 |
WHO-K | ≥32 | >32 | 64 | 4 | 2 | 2 | 0.125 | 0.25 | 0.25 | 0.063 | 0.063 | 0.063 | 2 | 2 | 2 | 0.5 | 0.25 | 0.5 |
WHO-L | ≥32 | >32 | 32 | 2 | 2 | 2 | 0.063 | 0.125 | 0.063 | 0.125 | 0.125 | 0.125 | 2 | 2 | 2 | 0.25 | 0.5 | 0.25 |
WHO-M | 0.25 | 2 | 1 | 4 | 2 | 2 | 0.031 | <0.016 | 0.016 | 0.031 | 0.016 | 0.016 | 128 | ≥32 | 32 | 0.5 | 0.25 | 0.5 |
WHO-N | 4 | 4 | 4 | ≥32 | 16 | 16 | 0.016 | <0.016 | 0.008 | 0.008 | 0.008 | 0.008 | 64 | >32 | 64 | 0.25 | 0.25 | 0.25 |
WHO-O | ≤0.004 | 0.008 | 0.016 | 4 | 2 | 4 | 0.031 | 0.016 | 0.032 | 0.031 | 0.032 | 0.032 | 128 | >32 | ≥256 | 0.5 | 0.25 | 0.5 |
WHO-P | ≤0.004 | 0.004 | 0.004 | 2 | 1 | 1 | 0.016 | <0.016 | 0.016 | 0.008 | 0.008 | 0.008 | 0.5 | 0.25 | 0.5 | 4 | 4 | 4 |
WHO-U | ≤0.004 | 0.004 | 0.004 | 1 | 1 | 2 | 0.016 | <0.016 | 0.004 | 0.008 | 0.004 | 0.004 | 1 | 0.125 | 0.5 | 4 | 4 | 4 |
WHO-V | 16 | >32 | 32 | 4 | 4 | 8 | 0.031 | <0.016 | 0.032 | 0.031 | 0.063 | 0.063 | ≥256 | >32 | ≥256 | ≥256 | >256 | ≥64 |
WHO-W | ≥32 | >32 | 64 | 4 | 4 | 4 | 0.125 | 0.25 | 0.25 | 0.063 | 0.125 | 0.125 | 2 | 4 | 8 | 0.5 | 0.5 | 0.25 |
WHO-X | ≥32 | >32 | 64 | 4 | 2 | 8 | 2 | 4 | ≥4 | 1 | 2 | 2 | 2 | 4 | 8 | 0.5 | 0.5 | 0.25 |
WHO-Y | 16 | >32 | 16 | 4 | 4 | 8 | ≥4 | 2 | ≥4 | 2 | 2 | 2 | 2 | 1 | 2 | 0.5 | 1 | 0.5 |
WHO-Z | ≥32 | >32 | 32 | 2 | 4 | 4 | 2 | 2 | 2 | 1 | 0.5 | 0.5 | 2 | 2 | 4 | 0.25 | 1 | 0.5 |
Agreement (%) | 92.9 | 85.7 | 100 | 100 | 100 | 92.9 | 100 | 100 | 92.9 | 85.7 | 92.9 | 100 |
ID, identifier.
MICpred, MICpub, and MICpheno represent predicted MIC, published MIC by Unemo et al. (18), and phenotypically determined MICs in this study, respectively. Values in bold identify MIC value differences greater than 2 doubling dilutions for each antimicrobial.