TABLE 1.

Correlation of antimicrobial MICs of WHO reference strains determined by logistic regression of molecular antimicrobial resistance determinants and phenotypically determined MICs

Strain IDa	MIC (mg/liter) data for drugb:
	Ciprofloxacin			Tetracycline			Cefixime			Ceftriaxone			Penicillin			Azithromycin
	MICpred	MICpub	MICpheno	MICpred	MICpub	MICpheno	MICpred	MICpub	MICpheno	MICpred	MICpub	MICpheno	MICpred	MICpub	MICpheno	MICpred	MICpub	MICpheno
WHO-F	≤0.004	0.004	0.004	≤0.25	0.25	0.5	≤0.008	<0.016	0.002	≤0.004	0.001	0.001	≤0.125	0.032	0.032	≤0.125	0.125	0.125
WHO-G	0.25	0.125	0.125	32	32	16	0.016	<0.016	0.016	0.008	0.008	0.008	1	0.5	0.5	0.25	0.25	0.25
WHO-K	≥32	>32	64	4	2	2	0.125	0.25	0.25	0.063	0.063	0.063	2	2	2	0.5	0.25	0.5
WHO-L	≥32	>32	32	2	2	2	0.063	0.125	0.063	0.125	0.125	0.125	2	2	2	0.25	0.5	0.25
WHO-M	0.25	2	1	4	2	2	0.031	<0.016	0.016	0.031	0.016	0.016	128	≥32	32	0.5	0.25	0.5
WHO-N	4	4	4	≥32	16	16	0.016	<0.016	0.008	0.008	0.008	0.008	64	>32	64	0.25	0.25	0.25
WHO-O	≤0.004	0.008	0.016	4	2	4	0.031	0.016	0.032	0.031	0.032	0.032	128	>32	≥256	0.5	0.25	0.5
WHO-P	≤0.004	0.004	0.004	2	1	1	0.016	<0.016	0.016	0.008	0.008	0.008	0.5	0.25	0.5	4	4	4
WHO-U	≤0.004	0.004	0.004	1	1	2	0.016	<0.016	0.004	0.008	0.004	0.004	1	0.125	0.5	4	4	4
WHO-V	16	>32	32	4	4	8	0.031	<0.016	0.032	0.031	0.063	0.063	≥256	>32	≥256	≥256	>256	≥64
WHO-W	≥32	>32	64	4	4	4	0.125	0.25	0.25	0.063	0.125	0.125	2	4	8	0.5	0.5	0.25
WHO-X	≥32	>32	64	4	2	8	2	4	≥4	1	2	2	2	4	8	0.5	0.5	0.25
WHO-Y	16	>32	16	4	4	8	≥4	2	≥4	2	2	2	2	1	2	0.5	1	0.5
WHO-Z	≥32	>32	32	2	4	4	2	2	2	1	0.5	0.5	2	2	4	0.25	1	0.5
Agreement (%)		92.9	85.7		100	100		100	92.9		100	100		92.9	85.7		92.9	100

^aID, identifier.

^bMIC_pred, MIC_pub, and MIC_pheno represent predicted MIC, published MIC by Unemo et al. (18), and phenotypically determined MICs in this study, respectively. Values in bold identify MIC value differences greater than 2 doubling dilutions for each antimicrobial.