TABLE 2.
Antimicrobial | Data seta | No. of isolates matching MIC dilutions ofb: |
% ±1 doubling dilution | Sensitivity (%)d | Specificity (%)d | % MIC interpretive errorsc |
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
>−2 | −2 | −1 | 0 | +1 | +2 | >2 | MI | MA | VMA | |||||
Ceftriaxone | Canada | 0 | 48 | 612 | 363 | 65 | 7 | 0 | 95.0 | NA | 100 | NB | 0 | 0 |
UK/USA | 18 | 61 | 157 | 133 | 51 | 9 | 2 | 79.1 | NA | 100 | NB | 0 | 0 | |
Cefixime | Canada | 0 | 23 | 204 | 615 | 228 | 22 | 3 | 95.6 | NA | 100 | NB | 0 | 0 |
UK/USA | 10 | 20 | 119 | 126 | 117 | 36 | 3 | 84.0 | NA | 100 | NB | 0 | 0 | |
Azithromycin | Canada | 16 | 73 | 187 | 754 | 60 | 2 | 3 | 91.4 | 99.7 | 81.2 | NB | 7.7 | 0.2 |
UK/USA | 12 | 14 | 73 | 114 | 134 | 77 | 7 | 74.5 | 77.3 | 99.8 | NB | 0.2 | 1.2 | |
Ciprofloxacin | Canada | 13 | 70 | 297 | 512 | 181 | 19 | 3 | 90.4 | 100 | 100 | 0.5 | 0 | 0 |
UK/USA | 7 | 14 | 31 | 258 | 106 | 5 | 10 | 91.7 | 100 | 98.8 | 1.9 | 0.5 | 0 | |
Tetracycline | Canada | 0 | 20 | 386 | 631 | 58 | 0 | 0 | 98.2 | 100 | 100 | 13.3 | 0 | 0 |
UK/USA | 8 | 15 | 101 | 152 | 127 | 22 | 6 | 88.2 | 99.7 | 88.0 | 19.0 | 0.7 | 0.2 | |
Penicillin | Canada | 13 | 67 | 423 | 487 | 101 | 4 | 0 | 92.3 | 100 | NA | 13.9 | 0 | 0 |
UK/USA | 60 | 53 | 125 | 106 | 72 | 15 | 0 | 70.3 | 100 | NA | 34.1 | 0.2 | 0 | |
Overall | Canada | 42 | 301 | 2,109 | 3,362 | 693 | 54 | 9 | 93.8 | 99.9 | 97.1 | 4.6 | 1.3 | 0.03 |
UK/USA | 115 | 117 | 606 | 889 | 607 | 164 | 28 | 81.3 | 99.2 | 99.5 | 9.2 | 0.3 | 0.2 |
Canadian validation data set, n = 1,095, and UK/U.S. international data set from Eyre et al. (28), n = 431.
The number of isolates with MICpred and MICpheno values that differ by the number of 2-fold dilutions.
The percentage of isolates with minor (MI), major (ME), and very major (VME) interpretative errors for susceptibilities. NB, no CLSI intermediate resistance interpretative breakpoints for these antimicrobials.
NA, too few isolates available with resistant or susceptible interpretative breakpoints were available to provide meaningful specificity or sensitivity values, respectively.