FIG 3.

Iron chelators are synergistic with TS against P. aeruginosa PA14. Checkerboards (A) and IC₅₀ isobolograms (B) are shown for each compound that synergized with TS. Dashed lines indicate the lines of additivity, and solid lines indicate the IC₅₀s of TS at each compound concentration. Checkerboards and IC₅₀ isobolograms are arranged in the following order: CO, CLI, TRO, DOXY, and GN from left to right, top to bottom. (C) Combination indices (CI) of each TS combination. CI values are indicated at the top of the bars. All experiments were conducted 3 times. Average values are reported. ****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05.