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Growth of highly resistant strain C0379 is inhibited with increased concentrations of CO, CLI, and DOXY. The resistant clinical isolate was challenged with single, double, and triple combinations of CO (A), CLI (B), DOXY (C), and TRO (D). Increasing doses of each compound were combined with TS and DSX at 8.3 μg/ml and 32 μg/ml, respectively. MIC assays were conducted at least 3 times and averaged results are shown. **, P < 0.001.
