FIG 1.

DIBI reduces S. aureus nares carriage in mice. Groups of 6 mice each were infected intranasally with MRSA strain ATCC 43300 and, at 2 dpi, were treated once intranasally with PBS (sham), MUP (10 μmol/kg), DIBI (11 μmol/kg), or MUP plus DIBI. Additional groups were treated at both 2 and 3 dpi. All groups were sacrificed at 5 dpi, and nares bacterial burdens were enumerated by plate counting. All treatments provided significant (P < 0.001) burden reductions over sham controls (significance not shown). Administration twice of DIBI provided a significant reduction compared with a single treatment, and administration twice of MUP plus DIBI provided a significant reduction compared with 2 administrations of MUP or DIBI alone. Dotted line indicates limit of detection. **, P < 0.01; ***, P < 0.001.