FIG 3.

HYD and CAR control acute Toxoplasma infection in mice. Female BALB/c mice were infected i.p. with an acute dose of 50,000 PLK tachyzoites and treated i.p. from day 1 to day 7 postinfection with 5 or 20 mg/kg HYD; 10, 25, or 50 mg/kg CAR; or PBS once daily. The body weight, morbidity, mortality, and clinical signs were noted. (A) Body weight (%). (B) Mean clinical scores. The scores varied from 0 (no signs) to 10 (all signs). (C) Survival rates. *, P < 0.05, log-rank (Mantel-Cox) test. (D) Parasite burdens of survival mice brains. At day 30 postinfection, the brains were collected, and DNA was extracted, 800 ng of DNA was used to detect the number of parasites. ***, P < 0.001, one-way ANOVA plus Tukey-Kramer post hoc analysis.