TABLE 1.
Baseline characteristicsa
| Patient characteristic (n = 18) | Value |
|---|---|
| Mean (SD) age (yr) | 63 (14.9) |
| No. (%) of male patients | 11 (61) |
| No. (%) of patients in the following location: | |
| Medical intensive care unit | 8 (44) |
| Neurosurgical intensive care unit | 5 (28) |
| Surgical intensive care unit | 4 (22) |
| Cardiac surgery intensive care unit | 1 (6) |
| Mean (SD) value for: | |
| Wt (kg) | 77.5 (21.6) |
| Serum creatinine concn (mg/dl) | 1.29 (1.15) |
| CLCRb (ml/min) | 78.2 (40.7) |
| APACHE II score | 24.2 (5.2) |
| SOFA score | 9.4 (4.1) |
| No. (%) of patients with infection at the following site: | |
| Respiratory | 9 (50) |
| Blood | 5 (28) |
| Urine | 2 (11) |
| Intra-abdominal | 1 (5.5) |
| Wound | 1 (5.5) |
| No. (%) of patients infected with the following organism: | |
| Pseudomonas aeruginosa | 7 (39) |
| Klebsiella pneumoniae | 3 (17) |
| E. coli | 2 (11) |
| Enterobacter spp. | 2 (11) |
| Serratia spp. | 1 (5.5) |
| Klebsiella oxytoca | 1 (5.5) |
| Shewanella putrefaciens | 1 (5.5) |
| Proteus spp. | 1 (5.5) |
| No. (%) of patients receiving the following piperacillin-tazobactam dose at the indicated interval: | |
| 4.5 g i.v. over 30 min q6h | 6 (33) |
| 4.5 g i.v. over 30 min q8h | 1 (6) |
| 3.375 g i.v. over 30 min q6h | 8 (44) |
| 2.25 g i.v. over 30 min q6h | 3 (17) |
a
APACHE II, Acute Physiology and Chronic Health Evaluation II; SOFA, Sequential Organ Failure Assessment; i.v., intravenous; q6h, every 6 h; q8h, every 8 h.
b
CLCR was calculated according to the Cockcroft-Gault equation.