TABLE 2.
Final population PK model parameter estimatesc
| Population parameter | Mean estimate | % RSE | % BSV | Shrinkage | Bootstrap median (n = 500) | Bootstrap 95% CI |
|---|---|---|---|---|---|---|
| CL (liters/h)a | 5.27 | 31.6 | 68 | 0.101 | 4.33 | 2.22–9.06 |
| V (liters)b | 20.0 | |||||
| CLCR effect on CL | 0.336 | 74.1 | 0.179 | 0.051–0.712 | ||
| RUV proportional error (%) | 44.1 | 30.2 | 0.299 | 45.6 | 16.6–71.5 |
a
CL = 5.27 · (CLCR/120)0.33.
b
V = 20 · (TBW/70)1.0, where TBW is total body weight.
c
CL, clearance; V, volume of distribution; CLCR, creatinine clearance; BSV, between-subject variability; RUV, residual unexplained variability; RSE: relative standard error; CI, confidence interval.