TABLE 1.
Lead compounds exhibit antimicrobial activity against Gram-positive bacteria and Gram-negative bacteria with outer membrane defectsa
| Strain | MIC (μM) |
||||
|---|---|---|---|---|---|
| Compound 5 | Compound 8 | Compound 33 | Compound 43 | Compound 44 | |
| Bacillus subtilis 168 | 1.25 | >20 | >20 | 20 | >20 |
| Staphylococcus aureus | |||||
| 12600 | 1.25 | >20 | 10 | >20 | >20 |
| MU50 | 0.63 | 20 | 10 | 20 | >20 |
| Enterococcus faecium 19434 | 1.25 | 20 | 10 | 20 | >20 |
| Escherichia coli | |||||
| W3110 | >20 | >20 | >20 | >20 | >20 |
| WD101 | >20 | >20 | >20 | >20 | >20 |
| WBBO6 | 2.5 | 20 | >20 | >20 | >20 |
| W3LPTD | 2.5 | 20 | 5 | >20 | >20 |
| WDLPXC | 5 | >20 | 20 | 20 | >20 |
a
Representative data from at least two biological replicates were generated for all strains using broth dilution assays.