FIG 1.

Survival of immunosuppressed mice infected with S. apiospermum DI16-478. ICR male mice (n = 10 to 20) were infected with an average inoculum of 3.0 × 10⁷ spores of S. apiospermum DI16-478 per mouse via inhalation. Treatment was initiated 16 h after infection and continued daily for 7 days. A dose of 50 mg/kg ABT was administered orally 2 h prior to fosmanogepix dose in all groups except the 52-mg/kg and 104-mg/kg (BID, without ABT) groups, as indicated. The nonparametric log-rank test was used to determine differences in survival times. P values versus placebo (ABT) were 0.004 (**) and <0.05 (*); P values versus placebo (without ABT) for POSA, L-AMB, and fosmanogepix (104 mg/kg and 52 mg/kg without ABT) did not achieve statistical significance (P > 0.16).