FIG 3.

Histological examination of brain harvested from mice infected with S. apiospermum and treated with placebo, fosmanogepix, or L-AMB. Mice were infected and treated as described for Fig. 2. Harvested fixed brains were stained with GMS prior to microscopic examination. Notice the intact hyphae in the placebo control group. Treatment with fosmanogepix plus ABT or L-AMB resulted in normal brain architecture with no signs of fungal dissemination.