TABLE 1.
Antifungal susceptibility profile of MGX and comparator agents
| Clinical isolate | MIC/MEC (μg/ml) |
|||
|---|---|---|---|---|
| MGX | POSA | VORI | AMB | |
| Scedosporium apiospermum DI16-476 | 0.03 | 1.0 | 0.5 | 4.0 |
| Scedosporium apiospermum DI16-477 | 0.03 | 0.5 | NDb | 2.0 |
| Scedosporium apiospermum DI16-478a | 0.03 | 0.5 | 1.0 | 1.0 |
| Scedosporium boydii DI16-479 | 0.03 | 0.25 | 1.0 | 8.0 |
| Scedosporium boydii DI16-480 | 0.03 | 2.0 | 1.0 | 4.0 |
| Scedosporium boydii DI16-481 | 0.03 | 4.0 | 1.0 | 2.0 |
| Lomentospora prolificans DI16-482 | 0.03 | >16 | >16 | >16 |
| Lomentospora prolificans DI16-483 | 0.03 | >16 | >16 | 8 |
| Lomentospora prolificans DI16-484 | 0.03 | >16 | >16 | >16 |
| Fusarium solani 95-2478a | 0.03 | >16 | 2 | 2 |
| Fusarium solani DI19-284 | ≤0.015 | 4 | 2 | 1 |
| Fusarium solani DI19-285 | ≤0.015 | 8 | 2 | 0.25 |
| Fusarium solani DI19-286 | ≤0.015 | >16 | 16 | 1 |
| Fusarium solani DI19-287 | ≤0.015 | >16 | >16 | 2 |
| Fusarium solani DI19-288 | ≤0.015 | >16 | >16 | 0.5 |
| Fusarium solani DI19-289 | ≤0.015 | >16 | 8 | 1 |
| Fusarium solani DI19-290 | ≤0.015 | >16 | >16 | 2 |
| Fusarium solani DI19-291 | ≤0.015 | >16 | >16 | 0.5 |
| Fusarium solani DI19-292 | ≤0.015 | >16 | 16 | 2 |
a
Strain used in the mouse infection model.
b
ND, not determined.