TABLE 3.
Model-estimated secondary pharmacokinetic parametersa
| Time period |
Cmax (mg/liter) for: |
AUC0–24 (mg · h/liter) for: |
||||
|---|---|---|---|---|---|---|
| Isoniazid | Pyrazinamide | Ethambutol | Isoniazid | Pyrazinamide | Ethambutol | |
| Prepartum | 1.39 (1.13–1.60) | 35.9 (32.7–38.1) | 1.82 (1.61–2.14) | 6.88 (3.63–10.40) | 419 (370–541) | 16.5 (14.3–20.6) |
| Postpartum | 1.43 (1.09–1.86) | 34.5 (29.9–41.3) | 2.11 (1.85–2.46) | 5.01 (2.89–8.03) | 407 (336–514) | 19.0 (16.5–21.6) |
a
Data are given as medians (interquartile ranges). For INH, there were 21 (3 at birth) prepartum and 16 postpartum women; for PZA and EMB, there were 15 (2 at birth) prepartum and 4 postpartum women.