TABLE 1.
Comparison of in vitro antimicrobial activity of OMC and various common antibiotics against E. faecalis
| Antibiotic | Resistance rate (%) | MIC breakpoint (μg/ml) | No. of isolates | MIC distribution and statistics for: |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OMC |
DOX |
MIN |
||||||||||||||||
| No. of isolates with MIC (mg/liter) of: |
Range (mg/liter) | MIC50/90 (mg/liter) | No. of isolates with MIC (mg/liter) of: |
Range (mg/liter) | MIC50/90 (mg/liter) | No. of isolates with MIC (mg/liter) of: |
Range (mg/liter) | MIC50/90 (mg/liter) | ||||||||||
| ≤0.25 | 0.5 | ≥1 | ≤4 | 8 | ≥16 | ≤4 | 8 | ≥16 | ||||||||||
| Total (276) | 72 | 166 | 38 | ≤0.125–1 | 0.5/1 | 39 | 18 | 219 | 0.125–32 | 16/32 | 42 | 30 | 204 | 0.125–32 | 16/32 | |||
| Tetracycline | 83.7 | ≤4 | 39 | 17 | 21 | 1 | 0.125–1 | 0.5/0.5 | 35 | 4 | 0 | 0.125–8 | 0.25/4 | 37 | 1 | 1 | 0.125–16 | 0.125/4 |
| 8 | 6 | 2 | 4 | 0 | 0.125–0.5 | 0.5/0.5 | 2 | 0 | 4 | 4–16 | 4/16 | 2 | 1 | 3 | 4–16 | 8/16 | ||
| ≥16 | 231 | 53 | 141 | 37 | ≤0.125–1 | 0.5/1 | 2 | 14 | 215 | 4–32 | 16/32 | 3 | 28 | 200 | 0.25–32 | 16/32 | ||
| Linezolid | 4.7 | ≤2 | 212 | 59 | 124 | 29 | ≤0.125–1 | 0.5/1 | 33 | 16 | 163 | 0.125–32 | 16/32 | 36 | 25 | 151 | 0.125–32 | 16/32 |
| 4 | 51 | 10 | 32 | 9 | ≤0.125–1 | 0.5/1 | 5 | 1 | 45 | 0.125–32 | 16/32 | 5 | 2 | 44 | 0.125–32 | 16/32 | ||
| ≥8 | 13 | 3 | 10 | 0 | 0.125–0.5 | 0.5/0.5 | 1 | 1 | 11 | 0.5–32 | 16/32 | 1 | 3 | 9 | 0.125–32 | 16/16 | ||
| Vancomycin | 0 | ≤4 | 274 | 71 | 165 | 38 | ≤0.125–1 | 0.5/1 | 38 | 18 | 218 | 0.125–32 | 16/32 | 41 | 30 | 203 | 0.125–32 | 16/32 |
| 8–16 | 2 | 1 | 1 | 0 | 0.125–0.5 | 1 | 0 | 1 | 0.25–16 | 1 | 0 | 1 | 0.5–16 | |||||
| Ampicillin | 0.4 | ≤8 | 275 | 71 | 166 | 38 | ≤0.125–1 | 0.5/1 | 38 | 18 | 219 | 0.125–32 | 16/32 | 41 | 30 | 204 | 0.125–32 | 16/32 |
| ≥16 | 1 | 1 | 0 | 0 | 0.125 | 1 | 0 | 0 | 0.25 | 1 | 0 | 0 | 0.5 | |||||
| Gentamycin | 68.5 | ≤4 | 40 | 19 | 18 | 3 | ≤0.125–1 | 0.5/0.5 | 13 | 3 | 24 | 0.125–32 | 16/32 | 12 | 5 | 23 | 0.125–32 | 16/16 |
| 8 | 47 | 14 | 27 | 6 | ≤0.125–1 | 0.5/1 | 10 | 4 | 33 | 0.125–32 | 16/32 | 12 | 4 | 31 | 0.125–32 | 16/32 | ||
| ≥16 | 189 | 39 | 121 | 29 | ≤0.125–1 | 0.5/1 | 16 | 11 | 162 | 0.125–32 | 16/32 | 18 | 21 | 150 | 0.125–32 | 16/32 | ||
| Erythromycin | 76.8 | ≤0.5 | 8 | 1 | 6 | 1 | 0.25–1 | 0.5/1 | 5 | 1 | 2 | 0.125–16 | 0.25/16 | 5 | 1 | 2 | 0.125–16 | 0.125/16 |
| 1–4 | 56 | 21 | 29 | 6 | 0.25–1 | 0.5/1 | 18 | 2 | 36 | 0.125–32 | 16/32 | 20 | 4 | 32 | 0.125–32 | 16/32 | ||
| ≥8 | 212 | 50 | 131 | 31 | ≤0.125–1 | 0.5/1 | 16 | 15 | 181 | 0.125–32 | 16/32 | 17 | 25 | 170 | 0.125–32 | 16/32 | ||
| Ciprofloxacin | 26.1 | ≤1 | 168 | 48 | 98 | 22 | ≤0.125–1 | 0.5/1 | 22 | 14 | 132 | 0.125–32 | 16/32 | 23 | 17 | 128 | 0.125–32 | 16/32 |
| 2 | 36 | 7 | 23 | 6 | 0.125–1 | 0.5/1 | 10 | 1 | 25 | 0.125–32 | 16/32 | 10 | 1 | 25 | 0.125–32 | 16/32 | ||
| ≥4 | 72 | 17 | 45 | 10 | ≤0.125–1 | 0.5/1 | 7 | 3 | 62 | 0.125–32 | 16/32 | 9 | 12 | 51 | 0.125–32 | 16/32 | ||
| Nitrofurantoin | 0.7 | ≤32 | 270 | 71 | 162 | 37 | ≤0.125–1 | 0.5/1 | 38 | 17 | 215 | 0.125–32 | 16/32 | 41 | 29 | 200 | 0.125–32 | 16/32 |
| 64 | 4 | 1 | 2 | 1 | 0.25–1 | 0.5/1 | 0 | 0 | 4 | 16–32 | 16/32 | 0 | 0 | 4 | 16–32 | 16/32 | ||
| ≥128 | 2 | 0 | 2 | 0 | 0.5 | 1 | 1 | 0 | 4–8 | 1 | 1 | 0 | 4–8 | |||||
| Trimethoprim-sulfamethoxazole | 14.1 | ≤2/38 | 237 | 66 | 140 | 31 | ≤0.125–1 | 0.5/1 | 35 | 16 | 186 | 0.125–32 | 16/32 | 39 | 22 | 176 | 0.125–32 | 16/32 |
| ≥4/76 | 39 | 6 | 26 | 7 | 0.25–1 | 0.5/1 | 4 | 2 | 33 | 0.25–32 | 16/32 | 3 | 8 | 28 | 0.125–32 | 16/32 | ||