TABLE 2.
In vitro antimicrobial activity of OMC against E. faecalis with TET-specific resistance genes
| TET resistance gene(s) | Total no. of isolates | MIC distribution and statistics for: |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OMC |
DOX |
MIN |
||||||||||||||
| No. of isolates with MIC (mg/liter) of: |
MIC range (mg/liter) | MIC50/90 (mg/liter) | No. of isolates with MIC (mg/liter) of: |
MIC range (mg/liter) | MIC50/90 (mg/liter) | No. of isolates with MIC (mg/liter) of: |
MIC range (mg/liter) | MIC50/90 (mg/liter) | ||||||||
| ≤0.25 | 0.5 | ≥1 | ≤4 | 8 | ≥16 | ≤4 | 8 | ≥16 | ||||||||
| tet(M) | 162 | 40 | 104 | 18 | ≤0.125–1 | 0.5/1 | 5 | 14 | 143 | 0.25–32 | 16/32 | 5 | 23 | 134 | 0.5–32 | 16/32 |
| tet(L) | 5 | 2 | 1 | 2 | 0.125–1 | 0.5/1 | 2 | 0 | 3 | 0.125–32 | 16/32 | 2 | 0 | 3 | 0.125–32 | 16/32 |
| tet(M), tet(L) | 60 | 16 | 31 | 13 | ≤0.125–1 | 0.5/1 | 2 | 1 | 57 | 4–32 | 32/32 | 4 | 3 | 53 | 0.25–32 | 16/32 |
| tet(M), tet(K) | 4 | 0 | 2 | 2 | 0.5–1 | 0.5/1 | 0 | 0 | 4 | 16 | 16/16 | 0 | 2 | 2 | 8–16 | 8/16 |
| tet(M), tet(L), tet(K) | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 32 | 0 | 0 | 1 | 16 | |||
| None detected | 44 | 14 | 28 | 2 | 0.125–1 | 0.5/0.5 | 30 | 3 | 11 | 0.125–32 | 0.5/16 | 31 | 3 | 10 | 0.125–32 | 0.25/16 |