TABLE 2.
Bacterial burdens at 24 h as determined by viable plating and flow cytometric analyses
| Antibiotic(s) | Log10 CFU/ml at 24 ha |
|||||
|---|---|---|---|---|---|---|
| AB 112 |
AB 8879 |
AB 9780 |
||||
| Viable plating | Flow cytometry | Viable plating | Flow cytometry | Viable plating | Flow cytometry | |
| No antibiotic | 9.13 | 9.31 | 9.15 | 9.11 | 9.36 | 9.30 |
| Polymyxin B | 3.73 | 6.20 | 6.79 | 5.07 | 1.60 | 4.98 |
| Rifampin | 2.34 | 5.77 | 2.60 | 5.00 | 8.62 | 8.77 |
| Meropenem | 7.33 | 8.32 | 8.56 | 8.62 | 8.75 | 8.83 |
| Polymyxin B + meropenem | 0.00 | 5.28 | 0.00 | 5.05 | 4.08 | 5.05 |
| Polymyxin B + rifampin | 3.22 | 5.58 | 0.00 | 5.00 | 0.00 | 4.83 |
a
Bactericidal combinations (≥3-log10 CFU/ml reduction in bacterial counts from the original inoculum) are in boldface type. The lower limit of detection for viable plating is 2.60 log CFU/ml.