TABLE 1.

Cumulative percentage of all clinical isolates of Enterobacteriaceae, individual genera/species of Enterobacterales, A. baumannii, P. aeruginosa, and S. maltophilia tested from 2013 to 2017 inhibited by eravacycline, by MIC

Organism	No. of isolates	Cumulative % of isolates inhibited by eravacycline at the following MIC (μg/ml)a:
		≤0.015	0.03	0.06	0.12	0.25	0.5	1	2	4	8	16	>16
All isolates
Enterobacteriaceae	10,531		<0.1	2.4%	30.0	73.2	92.6	96.9	98.9	99.8	>99.9	100
Klebsiella spp.	4,965			0.7	23.2	73.0	90.6	95.8	98.6	99.7	>99.9	100
Enterobacter spp.	1,820			<0.1	3.0	43.1	89.6	95.5	98.0	99.7	100
Citrobacter spp.	1,776			1.0	37.4	81.9	94.6	98.3	99.8	100
E. coli	1,970		0.2	9.9	65.4	94.0	98.8	99.7	100
P. mirabilis	1,348				0.1	1.4	10.6	48.3	91.8	99.6	99.8	99.9	100
S. marcescens	948				0.1	0.6	10.3	67.1	95.6	99.3	100
A. baumannii	2,097	1.0	7.3	18.4	28.9	42.3	70.5	92.5	98.7	99.6	99.9	100
P. aeruginosa	1,647		0.1		0.2	0.3	1.0	2.9	6.7	37.2	78.2	96.6	100
S. maltophilia	1,210		0.1	0.4	2.8	13.5	41.7	77.9	93.6	98.9	99.9	100
MDR isolatesb
Enterobacteriaceae	2,051		<0.1	1.5	18.3	55.0	80.5	91.3%	96.8	99.5	>99.9	100
Klebsiella spp.	801			0.4	8.5	43.7	72.4	88.0	95.1	99.0	99.9	100
Enterobacter spp.	448				1.6	32.6	73.4	86.4	94.4	99.3	100
Citrobacter spp.	247			0.4	17.4	55.5	80.2	91.9	99.2	100
E. coli	555		0.2	4.7	46.5	89.2	98.0	99.6	100
P. mirabilis	328					0.6	7.9	37.5	82.9	98.8	99.1	99.7	100
S. marcescens	87						4.6	43.7	86.2	97.7	100
A. baumannii	1,502		0.1	1.4	7.4	21.5	59.1	89.5	98.1	99.4	99.9	100
P. aeruginosa	339						0.3	3.2	6.2	21.2	56.0	90.6	100

^aThe MIC₉₀ is shaded gray.

^bMDR was defined using CLSI breakpoints.