TABLE 1.
In vitro activity of T-3207, fluconazole, and caspofungin against 23 C. auris isolatesa
| Activity level | T-2307 at 50% inhibition (μg/ml) | T-2307 at 100% inhibition (μg/ml) | Fluconazole at 50% inhibition (μg/ml) | Caspofungin at 50% inhibition (μg/ml) |
|---|---|---|---|---|
| MIC range | ≤0.008–0.015 | 0.125–>4 | 0.5–>64 | ≤0.015–>8 |
| MIC50 | 0.015 | >4 | 4 | 0.25 |
| MIC90 | 0.015 | >4 | >64 | 0.5 |
| GM MIC | 0.011 | 2.189 | 14.6 | 0.24 |
a
MICs read after 24 h of incubation at 35°C. MIC50 and MIC90, lowest concentrations that inhibited 50% and 90%, respectively, of the isolates tested; GM MIC, geometric mean MIC.