TABLE 1.
Main demographic and clinical characteristics of the study patientsa
Characteristic | Value |
---|---|
Median (range) age (yr) | 14.5 (3–18) |
No. (%) of children ages: | |
1 to <7 yr | 4 (14) |
7 to <12 yr | 5 (17) |
12 to <18 yr | 20 (69) |
No. (%) of male children | 20 (70) |
Median (range) wt (kg) | 47 (15–80) |
No. (%) of children who weighed: | |
<30 kg | 7 (24.1) |
>30 kg | 22 (75.9) |
No. (%) of children who used ISA after: | |
Chemotherapy | 10 (34.4) |
HSCT | 19 (65.5) |
No. (%) of children with the following underlying disease: | |
Acute lymphoblastic leukemia | 16 (55) |
Acute myeloid leukemia | 8 (27.6) |
Lymphoma | 3 (10.3) |
Congenital bone marrow failure | 1 (3.4) |
MDS | 1 (3.4) |
No. (%) of children with the following underlying disease status at IFD diagnosis: | |
First complete remission | 17 (63) |
Second complete remission or more | 5 (18.5) |
Relapse | 5 (18.5) |
No. (%) of children with the following outcome: | |
Alive | 25 (86.2) |
Dead | 4 (13.8) |
No. (%) of children with the following cause of death: | |
Relapse of underlying disease | 2 (50) |
PP-IFD | 1 (25) |
Otherb | 1 (25) |
Data are for 29 patients. Abbreviations: MDS, myelodysplasia; HSCT, hematopoietic stem cell transplantation; PP-IFD, proven/probable invasive fungal disease.
Transplant-related multiorgan failure.