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Kill curve activity of simulations for OXA administered at 2 g every 6 h in the ex vivo SEV model in standard media and NaHCO3-supplemented media against MRSA strains 11-11 (A), MW2 (B), COL (C), and BMC-1001 (D). The dashed line represents untreated growth in CAMHB-Tris; the solid lines indicate OXA regimens. *, P < 0.05 versus CAMHB; **, P < 0.05 versus CAMHB plus 25 mM NaHCO3 media.
