TABLE 2.
Pharmacokinetics of CFZ and OXA in the central compartment (medium) of the pharmacodynamic modela
| Parameter | CFZ, 2 g every 8 h |
OXA, 2 g every 6 h |
||
|---|---|---|---|---|
| Predicted | Observed (n = 12) | Predicted | Observed (n = 12) | |
| Cmax (mg/liter) | 256 | 249.4 ± 2.7 | 150 | 152.1 ± 1.4 |
| Cmin (mg/liter) | 16 | 15 ± 1 | 2.3 | 2.2 ± 0.1 |
| ke (h−1) | 0.385 | 0.354 ± 0.032 | 0.693 | 0.705 ± 0.005 |
| Half-life (h) | 1.8 | 2.0 ± 0.2 | 1 | 1.0 ± 0.0b |
| AUC0–24 (mg/liter ⋅ h) | 2,442 | 2,384 ± 31 | 1162 | 1,217 ± 91 |
a
Data for observed values are presented as means ± the standard errors.
b
The standard error for this value was <0.01.