TABLE 1.
Antimicrobial susceptibility of Enterobacterales, P. aeruginosa and resistant subsets collected in 2014–2018 from patients hospitalized with pneumonia and VAP
| Antimicrobial agent | PHP |
VAP |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MIC (mg/liter) |
N | CLSI (%)a |
MIC (mg/liter) |
N | CLSI (%)a |
|||||
| 50% | 90% | S | R | 50% | 90% | S | R | |||
| Enterobacterales | 4,790 | 814 | ||||||||
| Meropenem-vaborbactam | 0.03 | 0.06 | >99.9 | <0.1 | 0.03 | 0.06 | 100.0 | 0.0 | ||
| Meropenem | 0.03 | 0.06 | 97.2 | 2.3 | 0.03 | 0.06 | 98.3 | 1.5 | ||
| Imipenem | 0.25 | 1 | 92.8 | 3.6 | 0.25 | 1 | 94.3 | 2.2 | ||
| Cefepime | ≤0.5 | 8 | 87.8b | 9.2 | ≤0.5 | 2 | 92.4 | 5.5 | ||
| Ceftazidime | 0.25 | 32 | 82.8 | 15.6 | 0.25 | 32 | 85.3 | 13.4 | ||
| Ceftriaxone | 0.12 | >8 | 77.7 | 20.6 | 0.12 | >8 | 80.6 | 17.2 | ||
| Piperacillin-tazobactam | 2 | 64 | 87.3 | 7.1 | 2 | 64 | 87.0 | 7.5 | ||
| Aztreonam | ≤0.12 | >16 | 82.3 | 16.4 | ≤0.12 | >16 | 84.0 | 14.6 | ||
| Amikacin | 2 | 4 | 98.7 | 0.3 | 2 | 4 | 99.1 | 0.1 | ||
| Gentamicin | ≤1 | 2 | 91.3 | 7.5 | ≤1 | ≤1 | 95.3 | 3.6 | ||
| Tigecyclinec | 0.25 | 1 | 96.6 | 0.3 | 0.25 | 1 | 97.1 | 0.2 | ||
| Levofloxacin | ≤0.12 | >4 | 80.7 | 16.8 | ≤0.12 | >4 | 84.3 | 12.8 | ||
| Colistind | ≤0.5 | >8 | 76.1 | 23.9 | ≤0.5 | >8 | 77.8 | 22.2 | ||
| CREe | 131 | 13 | ||||||||
| Meropenem-vaborbactam | 0.03 | 0.5 | 98.5 | 0.8 | 0.06 | 1 | 100.0 | 0.0 | ||
| Meropenem | 16 | >32 | 3.8 | 85.5 | 4 | 32 | 0.0 | 92.3 | ||
| Imipenem | >8 | >8 | 0.0 | 98.5 | 8 | >8 | 0.0 | 84.6 | ||
| Cefepime | >16 | >16 | 8.4c | 77.9 | 16 | >16 | 30.8 | 53.8 | ||
| Ceftazidime | >32 | >32 | 4.6 | 93.1 | >32 | >32 | 15.4 | 76.9 | ||
| Ceftriaxone | >8 | >8 | 2.3 | 96.9 | >8 | >8 | 0.0 | 92.3 | ||
| Piperacillin-tazobactam | >64 | >64 | 3.8 | 89.3 | >64 | >64 | 7.7 | 61.5 | ||
| Aztreonam | >16 | >16 | 1.5 | 96.9 | >16 | >16 | 7.7 | 84.6 | ||
| Amikacin | 8 | 32 | 73.3 | 6.1 | 2 | 32 | 84.6 | 7.7 | ||
| Gentamicin | 4 | >8 | 52.7 | 26.7 | ≤1 | >8 | 76.9 | 15.4 | ||
| Tigecyclinec | 0.5 | 2 | 96.9 | 1.5 | 0.5 | 1 | 100.0 | 0.0 | ||
| Levofloxacin | >4 | >4 | 16.8 | 79.4 | 0.5 | >4 | 53.8 | 38.5 | ||
| Colistind | ≤0.5 | >8 | 76.9 | 23.1 | ≤0.5 | >8 | 84.6 | 15.4 | ||
| Pseudomonas aeruginosa | 3,193 | 545 | ||||||||
| Meropenem-vaborbactamd | 0.5 | 16 | 89.5 | 10.5 | 0.5 | 16 | 88.8 | 11.2 | ||
| Meropenem | 0.5 | 16 | 76.4 | 16.9 | 0.5 | 16 | 73.8 | 10.3 | ||
| Imipenem | 1 | >8 | 74.5 | 21.4 | 1 | >8 | 77.2 | 22.8 | ||
| Cefepime | 4 | 16 | 82.4 | 6.1 | 4 | 16 | 82.5 | 5.1 | ||
| Ceftazidime | 2 | 32 | 81.7 | 13.2 | 2 | 32 | 82.4 | 12.7 | ||
| Piperacillin-tazobactam | 4 | >64 | 77.5 | 11.7 | 8 | >64 | 74.3 | 11.9 | ||
| Aztreonam | 8 | >16 | 66.5 | 21.9 | 8 | >16 | 63.7 | 23.5 | ||
| Amikacin | 4 | 16 | 94.2 | 3.3 | 4 | 8 | 96.9 | 1.3 | ||
| Gentamicin | 2 | >8 | 82.5 | 10.3 | 2 | 8 | 85.0 | 9.0 | ||
| Levofloxacin | 1 | >4 | 62.0 | 26.7 | 0.5 | >4 | 67.7 | 23.9 | ||
| Colistin | 1 | 2 | 99.7 | 0.3 | 1 | 2 | 99.8 | 0.2 | ||
| MDRf P. aeruginosa | 697 | 124 | ||||||||
| Meropenem-vaborbactamd | 8 | 32 | 59.0 | 41.0 | 8 | 32 | 59.7 | 40.3 | ||
| Meropenem | 8 | 32 | 22.1 | 63.1 | 8 | 32 | 21.0 | 38.7 | ||
| Imipenem | 8 | >8 | 22.8 | 69.6 | 8 | >8 | 23.4 | 70.2 | ||
| Cefepime | 16 | >16 | 32.9 | 24.7 | 16 | >16 | 34.7 | 20.2 | ||
| Ceftazidime | 16 | >32 | 35.3 | 48.5 | 16 | >32 | 46.8 | 41.9 | ||
| Piperacillin-tazobactam | 64 | >64 | 23.0 | 43.6 | 64 | >64 | 19.4 | 41.1 | ||
| Aztreonam | >16 | >16 | 16.8 | 66.7 | >16 | >16 | 15.3 | 67.7 | ||
| Amikacin | 8 | >32 | 80.8 | 12.1 | 8 | 16 | 90.3 | 3.2 | ||
| Gentamicin | 8 | >16 | 44.9 | 35.7 | 8 | 16 | 49.2 | 33.1 | ||
| Levofloxacin | >4 | >4 | 9.2 | 74.5 | >4 | >4 | 14.5 | 69.4 | ||
| Colistin | 0.5 | 2 | 99.1 | 0.9 | 1 | 2 | 100.0 | 0.0 | ||
| XDRg P. aeruginosa | 440 | 70 | ||||||||
| Meropenem-vaborbactamd | 16 | 32 | 48.6 | 51.4 | 16 | 32 | 47.1 | 52.9 | ||
| Meropenem | 16 | 32 | 10.0 | 76.6 | 16 | 32 | 10.0 | 72.9 | ||
| Imipenem | >8 | >8 | 13.2 | 79.5 | 8 | >8 | 15.7 | 77.1 | ||
| Cefepime | 16 | >16 | 18.2 | 34.1 | 16 | >16 | 20.0 | 24.3 | ||
| Ceftazidime | 32 | >32 | 23.9 | 58.4 | 16 | >32 | 44.3 | 44.3 | ||
| Piperacillin-tazobactam | >64 | >64 | 8.9 | 53.2 | 64 | >64 | 2.9 | 48.6 | ||
| Aztreonam | >16 | >16 | 9.5 | 77.3 | >16 | >16 | 10.0 | 78.6 | ||
| Amikacin | 8 | >32 | 76.8 | 23.2 | 8 | 32 | 87.1 | 5.7 | ||
| Gentamicin | 8 | >16 | 37.0 | 41.8 | 8 | >16 | 40.0 | 40.0 | ||
| Levofloxacin | >4 | >4 | 2.5 | 83.6 | >4 | >4 | 1.4 | 81.4 | ||
| Colistin | 0.5 | 1 | 99.1 | 0.9 | 1 | 2 | 100.0 | 0.0 | ||