TABLE 2.
Distribution of carbapenemase genes detected among Enterobacterales isolates causing pneumonia in hospitalized patients in U.S. medical centers (2014 to 2018)
| Organism | Carbapenemase detected | No. of isolates | US census division(s) | MIC range (mg/liter) |
|
|---|---|---|---|---|---|
| Meropenem | Meropenem-vaborbactam | ||||
| Citrobacter freundii species complex | KPC-2 | 1 | Middle Atlantic | 2 | <0.015 |
| KPC-3 | 2 | Middle Atlantic | 8 to 16 | 0.03 | |
| Klebsiella oxytoca | KPC-2 | 2 | Mountain, East North Central | 2 to 32 | 0.03 |
| KPC-3 | 4 | Middle Atlantic, South Atlantic | 1 to 32 | 0.03 | |
| Klebsiella pneumoniae | KPC-2 | 21 | Middle Atlantic, West South Central | 1 to >32 | <0.015 to 2 |
| KPC-3 | 19 | Middle Atlantic, East North Central, Pacific | 2 to >32 | <0.015 to 1 | |
| Enterobacter cloacae species complex | KPC-3 | 10 | New England, Middle Atlantic, Mountain | 2 to >32 | 0.03 to 0.25 |
| Escherichia coli | KPC-3 | 1 | Middle Atlantic | 16 | 0.03 |
| Serratia marcescens | KPC-3 | 6 | Middle Atlantic, East North Central | 2 to >32 | 0.06 to 1 |
| SME-4 | 2 | Mountain, Middle Atlantic | >32 | 0.03 to 0.06 | |
| NDM-1 | 1 | Middle Atlantic | 4 | 8 | |
| Proteus mirabilis | IMP-64 | 1 | Mountain | 16 | 16 |