Figure 3.

Effect of Tumor Size at Time of RT and Treatment Duration on the Therapeutic Success Rate

(A and B) Dependence of the therapeutic success rate with recruitment rate of effector cells in response to tumor burden $0.40\le r\le 0.55$ and the functional degree of tumor-associated vascularity $0.1\le B\le 0.7$ on tumor radius before treatment (b.t.) and the number of treatment fractions for increasing strengths of tumor-specific immunity induced by radiation (η).

(C) Dependence of the therapeutic success rate with $0.40\le r\le 0.55$ for $0.1\le B\le 0.4$ and $0.4<B\le 0.7$ on the number of treatment fractions. Radiation was delivered at 2 Gy/day and 5 days/week in (A) 25 daily fractions or (B and C) increasing number of fractions.

(D) Model-predicted tumor responses to fractionation schemes consisting in 15 and 25 fractions at 2Gy/day and 5 days/week depending on tumor-associated vascularity (B) and the recruitment rate of effector cells in response to tumor burden (r). Tumor control (TC) (blue) and progressive disease (red) refer to tumor eradication and escape after treatment, respectively. Model simulations were performed with $\eta =8.0\times {10}^5$ cells day⁻¹, ${\lambda }_M=1.15$ day⁻¹, and a tumor size at time of RT equal to $R=15$ mm, unless indicated otherwise.

The remaining parameter values were as in Table S1 [Parameter values considered in model simulations].