Figure 4.

Effect of Tumor Size at Time of RT on Tumor Control and the Tumor-Immune Ecosystem after Treatment

(A) Model-predicted RT responses of tumors with different tumor size before treatment (b.t.), functional degree of tumor-associated vascularity (B), and recruitment rates of effector cells in response to tumor burden (r).

(B–D) (B) Amount of effector cells and (D) tumor size after treatment (a.t.), and (C) overall radiation-induced effector cells for increasing tumor size before treatment (b.t.) and different values of B. Radiation was delivered to a total dose of 50 Gy in 25 daily fractions at 2 Gy per day, 5 days per week. Tumor control (TC) (blue) and progressive disease (red) refer to tumor eradication and escape after treatment, respectively. Model simulations were performed with $\eta =8.0\times {10}^5$ cells day⁻¹ and ${\lambda }_M=1.15$ day⁻¹.

The remaining parameter values were as in Table S1 [Parameter values considered in model simulations].