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. 2020 Feb 12;32:101464. doi: 10.1016/j.redox.2020.101464

Fig. 1.

Fig. 1

Omeprazole induces cell death of both human and murine tubular cells. A) Murine (MCT) and human (HK-2 and RPTEC) tubular cells were exposed to different concentrations of omeprazole for 24h and 48h and cell viability was assessed by the MTT assay. Mean ± SD of three experiments *p < 0.05 vs vehicle; **p < 0.01 vs control; ***p < 0.001 vs control. B) Time-course of omeprazole-induced cell death in HK-2 cells stimulated with 300 μM omeprazole. Mean ± SD of three experiments ***p < 0.001 vs control. C) Phase contrast imaging of HK-2 cells stimulated with omeprazole. Magnification x200 (scale 100 μm) and detail x400 (scale 50 μm). Representative images of three experiments. D, E) HK-2 cells stimulated with low dose omeprazole for 7 days. (D) Cell viability Mean ± SD of five independent experiment; *p < 0.05 vs control; ***p < 0.001 vs control. (E) Representative images of three experiments. Magnification x200 (scale 100 μm) and detail x400 (scale 50 μm).