Fig. 11.

Bench mark response (BMR) for BDNF protein levels. The absolute BMR of single chemicals, based on the concentrations used in the mixtures ('3-Sim' in a, '3-Diss' in b, and 'All' in c), are plotted and compared with the absolute percentage of response experimentally observed in the mixtures for BDNF (normalised to control). Although the calculated TU was > 1, a combined/potentiated mixture effect can be hypothesized, in the case when the response elicited by the mixture was at least two-folds of magnitude higher than individual chemical contributions, as indicated by the orange dashed arrow