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. 2020 Feb 24;19:23. doi: 10.1186/s12940-020-00578-x

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© The Author(s) 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Analysis of cell viability upon treatments with single chemicals in hiPSC-derived NSCs undergoing differentiation. (a) hiPSC-derived NSCs were differentiated for 7 DIV, followed by 14 days treatment with different concentrations of individual chemicals. After 14 days (i.e., 21 DIV), resazurin test was performed (b-g). All samples were normalised to solvent control (0.1% DMSO, Ctr) at the respective time point. All chemicals were tested in 3 to 5 experimental replicates, considering 6 internal replicates for each concentration. After measurement, the normalised values were imported into GraphPad Prism, where a non-linear fit (sigmoidal dose-response (variable slope)) was performed in order to calculate the inhibitory concentration (IC) values reported in (b-g)