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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Alzheimers Dement. 2019 Oct 22;15(11):1489–1502. doi: 10.1016/j.jalz.2019.06.4954

Fig. 4: Rescue of tau induced cell cytotoxicity in SH-SY5Y human neuroblastoma cells by MK-886.

Fig. 4:

(A) SH-SY5Y cells were transfected with vector control and P301L tau. Significant cell death is observed in cells transfected with P301L tau as compared to the vector control. (B) MK-886 rescued P301L tau induced cytotoxicity in SH-SY5Y cells with an IC50 of 0.523 μM. Data are means ± SD of three independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001 by two-tailed unpaired t test.