| Methods |
Single center randomized study. Masking of allocation; not described. Masking of intervention; No. Completeness of follow up; Yes. Masking of outcome; No. |
| Participants |
30 term and preterm infants. |
| Interventions |
Heparin at 0.25 units/mL, or no heparin, in the infusate. Flush solutions did not contain heparin. |
| Outcomes |
Catheter occlusion, intraventricular hemorrhage, PT, PTT were only measured in the heparin group. Blue toes. |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
No details of the randomization process are given. |
| Allocation concealment? |
Unclear risk |
No method for masking allocation is described, no details of the randomization process are given. |
| Blinding?
All outcomes |
High risk |
Masking of intervention: Not attempted.
Masking of Outcome: Not attempted. |
| Incomplete outcome data addressed?
All outcomes |
Low risk |
Completeness of follow‐up:
All patients are accounted for. |
