| Methods |
From 07/1994 to 06/1997.
Randomised.
Adequate allocation concealment.
Outcome assesment blind.
3 patients excluded from the analysis and 3 patients lost to follow‐up.
Intention to treat. |
| Participants |
First ever ischaemic stroke in the carotid artery territory with impairment of conscioussness. Excluded: deep and depassè coma according to Bricolo's (1975) classification. Hemorrhagic, vertebrobasilar and lacunar stroke; impaired conscioussness due to causes other than stroke; renal hepatic and cardiac failure.
67 cases randomised,
F = 38, M = 29.
Mean age 75 years.
Time entry window: 12 hours. |
| Interventions |
Glycerol 10% i.v. in 500 ml in over 4 hours vs glycerol 10% i.v. in 500 ml b.i.d. vs avoid glycerol. |
| Outcomes |
Death at 7, 30 days, 6 and 12 months. Disability (Barthel index) and disability/handicap (modified Rankin Scale) at 6 and 12 months.
Side effects of treatment. |
| Notes |
Not published. No data available for 3 randomised patients. 1 patient in avoid glycerol, 2 patients in glycerol low dose lost at follow‐up.
Low and high doses of glycerol considered together. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
