| Methods |
Randomised.
Concealment: open list of random numbers.
Double‐blind.
13 excluded from the analysis.
Non intention to treat. |
| Participants |
Probable ischaemic stroke in the middle cerebral artery territory.
Excluded: signs of intracranial haemorrhage, TIA, lacunar stroke, cerebral tumour, heart failure.
51 patients considered in the analysis + 13 withdrawn
Mean age: 71 years. ?Sex.
Any severity considered.
Time window entry < 48 hours. |
| Interventions |
Glycerol i.v. in 250 ml of saline and glucose 5% or 250 ml of NaCl 0.9% and glucose 5% over 2 hours q.i.d. for 6 days. |
| Outcomes |
Death at 4 months.
Neurological and Global performances score system (original) at 7 days and 4 months.
Side effects of treatment. |
| Notes |
13 excluded from the analysis. 11 had exclusion criteria after randomisation, 1 treated with no considered drugs in the trial, 1 sudden deterioration.
Lumbar puncture in all patients. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
