| Methods |
From 5/1982 to 3/1984
Randomised.
Unknown allocation concealment.
Double blind
2 patients withdrawn. Intention‐to‐treat. |
| Participants |
Ischaemic stroke with hemiplegia.
Excluded: > 80 years, TIA, previous deficits from stroke, cerebral haemorrhage, tumour, treatment with anticoagulants. Renal, hepatic and cardiac failure.
38 patients, F = 12, M = 26.
Range 53 to 80 years; mean age 67 years.
Patients in coma not considered.
Time entry window: between 24 and 32 hours from onset. |
| Interventions |
Glycerol 10%i.v. in 500 ml followed by 500 ml placebo (glucose 2.5% plus NaCl 0.45%) vs 500 ml placebo + 500 ml placebo for 7 days.
(Only patients treated with glycerol/placebo vs placebo/placebo included in the review). |
| Outcomes |
Death at 7 days and 6 months
Neurological score (Modified Mathew scale)
at 7 days and 3 and 6 months.
Side effects of treatment. |
| Notes |
3 treatment regimes were considered in the trial but only patients treated with glycerol/placebo vs placebo/placebo are included in the review. 23 patients in the glycerol 10% in 500 ml followed by 50 g dextran plus 25 g dextrose in 500 ml followed by placebo 500 ml group were excluded.
CT scan in all patients. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
