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. 2019 Nov 9;37(3):904–922. doi: 10.1093/molbev/msz263

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© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — Tetrapod cladogram indicating the number of RELEC genes present in the model species for each of the main lineages, and in parentheses the percent of the total after accounting for the indicated duplication events. In red the percent of RELEC genes that are correctly annotated on Ensembl. Poor genome annotation outside of mammals is likely due to the rapid evolutionary rate of RELEC genes, as well as missing data in those genomes. Vertical dashes show the two exceptions where we allowed paralogs to be retained: two tandem duplications in PKDREJ in squamates and a duplication of CKAP5 in reptiles. Most of the RELEC genes are present in Xenopus, though some are reduced in length, and many are likely present in higher vertebrate lineages as well. Silhouttes from http://phylopic.org, used under the Creative Commons (https://creativecommons.org/licenses/by/3.0/), with drawings of Xenopus and Anolis by Sarah Werning, and painted turtle by Scott Hartman.