Extended Data Figure 9: Hyperexcitability in the glioma microenvironment and working model of neuron-glioma interactions in the tumor microenvironment.
a, Individual channel electrocorticography signals (mean high-gamma frequency-filtered power (μV2)) in each of healthy-appearing, tumor core, and tumor-infiltrated brain across three patients (n=23, n=29, n=51 total channels, respectively). b, Working model of glioma integration in neural circuity, with hyperexcitability of neurons (grey) exacerbating activity-dependent mechanisms of glioma (green) growth. 1, Neuron-to-glioma synapses, synaptic vesicles = red; AMPA receptors = grey. 2, Inward potassium (K+) current = blue, potassium channel = grey 3, Gap junction (white) coupling in glioma amplifies current.