Extended Data Table 1.
Characteristics of patient-derived high-grade glioma cell cultures / xenografts
| Culture ID | Tumor type, location and grade | Age at diagnosis (years) | Patient sex | Histone-3 mutational status | Other genomic characteristics | Timepoint tissue obtained | Prior therapy | Survival (months) |
|---|---|---|---|---|---|---|---|---|
| SU-pcGBM2 | Pediatric cortical glioblastoma; frontal lobe; WHO grade IV | 15 | M | WT | P53 mutated EGFR amplified | Biopsy at diagnosis | none | N/A |
| SU-DIPGVI | DIPG; pons; WHO grade IV | 7 | F | H3.3K27M | N/A | Early postmortem autopsy | XRT; vorinostat | 6 |
| SU-DIPGXIII-P* | DIPG; pons; WHO grade IV | 6 | F | H3.3K27M | N/A | Early postmortem autopsy | XRT | 4 |
| SU-DIPGXIII-FL | DIPG; frontal lobe met; WHO grade IV | 6 | F | H3.3K27M | N/A | Early postmortem autopsy | untreated | 4 |
| SU-DIPG25 | DIPG; pons; WHO grade IV | 5 (at death) | F | H3.3K27M | N/A | Early postmortem autopsy | XRT | 11 |
| SU-DIPG31 | DIPG; pons; WHO grade IV | 18 | M | H3.3K27M | N/A | Early postmortem autopsy | XRT; etoposide | N/A |
| SU-DIPG32 | DIPG; pons; WHO grade IV | 5 | M | H3.1K27M | N/A | Early postmortem autopsy | XRT; avastin | N/A |
| SU-DIPG33 | DIPG; pons; WHO grade IV | 8 | M | H3.1K27M | N/A | Early postmortem autopsy | XRT | N/A |
| SU-DIPG39 | DIPG; pons; WHO grade IV | 5 (at death) | M | H3.3K27M | N/A | Early postmortem autopsy | XRT | 6 |
| SU-GBM092 | GBM; hemispheric; WHO grade IV | 47 | M | N/A | N/A | Early postmortem autopsy | Resection; XRT; TMZ | 6 |
| SF0047 (human subject 1) | GBM; left temporal lobe; WHO grade IV | 57 | M | N/A | Neg IDH1 R132H; MGMT unmethylate d | Resection at diagnosis | none | N/A |
| SF0109 (human subject 2) | GBM; left parietal lobe; WHO grade IV | 63 | M | N/A | Neg IDH1 R132H | Resection at diagnosis | none | N/A |
| SF0144 (human subject 3) | HGG; left temporal lobe; WHO grade III | 74 | M | N/A | Neg IDH1 R132H; ATRX WT | Resection at diagnosis | none | N/A |
WHO = World Health Organization; DIPG = diffuse intrinsic pontine glioma; XRT = radiotherapy; TMZ = temozolomide. Note that SU-DIPGXIII-P* and SU-DIPGXIII-FL were tissue samples acquired from the same patient at autopsy; in this case the pontine tumor (P) received focal radiotherapy, whereas the frontal lobe (FL) tumor was an untreated metastasis from the primary pontine tumor to the frontal lobe.