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. 2020 Jan 8;48(4):1715–1729. doi: 10.1093/nar/gkz1206

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Systematic identification of m⁶A regulators. (A) Q-Q plot comparing the distributions of expected P-values and observed P-values of the correlations between the gene expressions of RBPs and m⁶A indexes of the co-methylation modules. (B) Heatmaps representing the m⁶A ratios of the m⁶A peaks within the module M15 (upper panel) and the gene expressions of the RBPs that significantly correlated with the m⁶A indexes of M15 (lower panel). The cell lines are sorted according to the m⁶A indexes of M15. (C andD) Barplot representing the percentages of the pairs of RBPs and modules that enriched for CLIP-seq binding sites (C) or motifs (D) of the RBPs out of the pairs that showing significant and non-significant (top 1000 least significant) correlations between gene expressions of the RBPs and the m⁶A indexes of the modules. (E) Venn diagram demonstrating the identification of 32 high-confidence m⁶A regulators. (F) Scatter plot showing the correlation between TRA2A gene expression and m⁶A indexes of module M15 across all cell lines. (G) Representative motifs enriched in module M15 and TRA2A CLIP-seq targets.