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. 2020 Jan 13;48(4):1652–1668. doi: 10.1093/nar/gkz1229

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — GG-NER reaction in chromatin. This scheme summarizes the major transitions of the GGR reaction cycle (from DNA damage recognition to the final DNA gap filling) and the ‘access-repair-restore’ model describing how this multistep process may take place in the nucleosome landscape of chromatin. The XPC subunit initiates GGR activity as part of a trimeric complex with HR23B and CETN2. KMTs favor the GGR reaction in the nucleosome context by constitutive and DNA damage-induced depositions of histone methylation marks.