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. 2019 Dec 19;48(4):1828–1842. doi: 10.1093/nar/gkz1179

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Formative target genes in naive pluripotency. (A) Boxplot for comparing H3K27me3 and H3K27ac signal at the promoter of AdaEnsemble-identified TF target genes of naive and formative TFs during pluripotency progression. (B) Time-course of average log₂ fold change (relative to 0 min) in mRNA expression for the target genes of naive and formative TFs. Shaded areas represent standard deviation among target genes. (C) Chromatin accessibility (ATAC-seq) of c-Myc, Otx2, and naive TF binding sites in ESCs and EpiLCs. (D) Schematic illustration of the poised chromatin associated with formative target genes in naive pluripotency.